ADRBK1 polyclonal antibody
产品名称： ADRBK1 polyclonal antibody
英文名称： ADRBK1 polyclonal antibody
产品编号： PAB4516
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ADRBK1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ADRBK1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo.
Li J, Xiang B, Su W, Zhang X, Huang Y, Ma L.J Biol Chem. 2003 Aug 8;278(32):30219-26. Epub 2003 May 15.
- 2.
- Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase.
Yang XL, Zhang YL, Lai ZS, Xing FY, Liu YH.World J Gastroenterol. 2003 Apr;9(4):800-3.
- 3.
- The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.
Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ.J Biol Chem. 2003 May 16;278(20):18658-63. Epub 2003 Mar 6.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of ADRBK1 polyclonal antibody (Cat # PAB4516) in Ramos cell lysate . ADRBK1 (arrow) was detected using purified ADRBK1 polyclonal antibody (Cat # PAB4516) . Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with ADRBK1 polyclonal antibody (Cat # PAB4516) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .
- Entrez GeneID:
- 156
- Protein Accession#:
- P25098
- Gene Name:
- ADRBK1
- Gene Alias:
- BARK1,BETA-ARK1,FLJ16718,GRK2
- Gene Description:
- adrenergic, beta, receptor kinase 1
- Omim ID:
- 109635
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq
- Other Designations:
- beta adrenergic receptor kinase 1
- Gene Pathway