RPTOR polyclonal antibody
产品名称： RPTOR polyclonal antibody
英文名称： RPTOR polyclonal antibody
产品编号： PAB13418
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of RPTOR.
- Immunogen:
- A synthetic peptide corresponding to N-terminus 13 amino acids of human RPTOR.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- Raptor has multiple isoforms that may also be recognized by antibody.
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression.
Fingar DC, Blenis J.Oncogene. 2004 Apr 19;23(18):3151-71.
- 2.
- Integration of growth factor and nutrient signaling: implications for cancer biology.
Shamji AF, Nghiem P, Schreiber SL.Mol Cell. 2003 Aug;12(2):271-80.
- 3.
- Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism.
Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J.J Biol Chem. 1998 Jun 5;273(23):14484-94.
- Entrez GeneID:
- 57521
- Protein Accession#:
- Q8N122
- Gene Name:
- RPTOR
- Gene Alias:
- KOG1,Mip1
- Gene Description:
- regulatory associated protein of MTOR, complex 1
- Omim ID:
- 607130
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats,regulatory associated protein of mTOR
- Gene Pathway