ABL1 polyclonal antibody
产品名称: ABL1 polyclonal antibody
英文名称: ABL1 polyclonal antibody
产品编号: PAB16983
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ABL1.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding Y412 of human ABL1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody detects endogenous levels of total ABL1 protein.
- Form:
- Liquid
- Storage Buffer:
- In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ.Cell. 2007 Dec 14;131(6):1190-203.
- 2.
- Autoinhibition of c-Abl.
Pluk H, Dorey K, Superti-Furga G.Cell. 2002 Jan 25;108(2):247-59.
- 3.
- JAK-STAT signaling activated by Abl oncogenes.
Danial NN, Rothman P.Oncogene. 2000 May 15;19(21):2523-31.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from K-562 cells.
Lane 1 : Using ABL1 polyclonal antibody (Cat # PAB16983).
Lane 2 : Using the same antibody preincubated with synthesized peptide.
- Entrez GeneID:
- 25
- Protein Accession#:
- P00519
- Gene Name:
- ABL1
- Gene Alias:
- ABL,JTK7,bcr/abl,c-ABL,p150,v-abl
- Gene Description:
- c-abl oncogene 1, receptor tyrosine kinase
- Omim ID:
- 189980
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq
- Other Designations:
- Abelson murine leukemia viral (v-abl) oncogene homolog 1,OTTHUMP00000022375,OTTHUMP00000022376,bcr/c-abl oncogene protein,proto-oncogene tyrosine-protein kinase ABL1,v-abl Abelson murine leukemia viral oncogene homolog 1
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Chronic Disease
- Diabetes Complications
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- HIV Infections
- Leukemia, chronic myeloid
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid
- Leukemia, Myeloid, Chronic
- Metabolic Syndrome X
- Neoplasms
- Osteoporosis
- Ovarian cancer