ITGAM monoclonal antibody, clone ICRF44
产品名称： ITGAM monoclonal antibody, clone ICRF44
英文名称： ITGAM monoclonal antibody, clone ICRF44
产品编号： MAB5619
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native ITGAM.
- Immunogen:
- Native purified ITGAM from rheumatoid synovial cells and human monocytes.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- human CD11b/Mac-1a.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In 100 mM BBS, pH 8.2
- Storage Instruction:
- Store at 4°C.
- Recommend Usage:
- Flow Cytometry (1 ug/106 cells)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the alphaMbeta2 integrin.
Zhang L, Plow EF.J Biol Chem. 1996 Jul 26;271(30):18211-6.
- 2.
- Integrins as promiscuous signal transduction devices.
Petty HR, Todd RF 3rd.Immunol Today. 1996 May;17(5):209-12.
- 3.
- Two conformations of the integrin A-domain (I-domain): a pathway for activation?
Lee JO, Bankston LA, Arnaout MA, Liddington RC.Structure. 1995 Dec 15;3(12):1333-40.
- Application Image
- Immunohistochemistry (Frozen sections)
- Flow Cytometry
- Entrez GeneID:
- 3684
- Gene Name:
- ITGAM
- Gene Alias:
- CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6
- Gene Description:
- integrin, alpha M (complement component 3 receptor 3 subunit)
- Omim ID:
- 120980
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- antigen CD11b (p170),complement component receptor 3, alpha,integrin alpha M,macrophage antigen alpha polypeptide,neutrophil adherence receptor alpha-M subunit
- Related Disease
- Autoimmune Diseases
- Cardiovascular Diseases
- Crohn's disease
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Genetic Predisposition to Disease
- Helicobacter Infections
- Lupus Erythematosus, Discoid
- Lupus Erythematosus, Systemic
- Lupus Nephritis
- Macular Degeneration
- Nephritis
- Stomach Ulcer