DUSP1 (C-term) Peptide
产品名称： DUSP1 (C-term) Peptide
英文名称： DUSP1 (C-term) Peptide
产品编号： P3318
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DUSP1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human DUSP1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival.
Wu W, Pew T, Zou M, Pang D, Conzen SD.J Biol Chem. 2005 Feb 11;280(6):4117-24. Epub 2004 Dec 7.
- 2.
- Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role.
Small GW, Shi YY, Edmund NA, Somasundaram S, Moore DT, Orlowski RZ.Mol Pharmacol. 2004 Dec;66(6):1478-90. Epub 2004 Sep 24.
- 3.
- Role of CL-100, a dual specificity phosphatase, in thrombin-induced endothelial cell activation.
Chandrasekharan UM, Yang L, Walters A, Howe P, DiCorleto PE.J Biol Chem. 2004 Nov 5;279(45):46678-85. Epub 2004 Aug 31.
- Entrez GeneID:
- 1843
- Protein Accession#:
- P28562
- Gene Name:
- DUSP1
- Gene Alias:
- CL100,HVH1,MKP-1,MKP1,PTPN10
- Gene Description:
- dual specificity phosphatase 1
- Omim ID:
- 600714
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq
- Other Designations:
- serine/threonine specific protein phosphatase
- Gene Pathway